• 6g Bonded LOLA per serving
  • Less than 1 calorie per scoop
  • GI Friendly
  • Made in the USA in an FDA inspected facility
  • Clinically Studied*
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About HepLOLA

HepLOLA is a medical food indicated to treat and prevent hepatic encephalopathy. HepLOLA is 6g of Bonded L-Ornithine-L-Aspartate (LOLA) per serving. The use of LOLA for the management of Hepatic Encephalopathy is clinically studied, effective, and safe for most people.

HepLOLA is also used to treat elevated ammonia and cognitive decline due to elevated ammonia in NALFD/NASH.

HepLOLA needs to be used, dosed and monitored under the care of a qualified health care professional.

Purchasing HepLOLA

HepLOLA can be ordered in the Buy HepLOLA section of this site. For outpatient use, a one month supply canister of HepatoLOLA has 90 servings. There is a scoop inside that has 6g of LOLA per scoop.

We offer standard ground and 2nd day air (3 day delivery time). We don't offer overnight shipping as the cost is prohibitive.

How HepLOLA treats Hepatic Encephalopathy and elevated ammonia due to NAFLD/NASH

L-Ornithine L-Aspartate lowers plasma ammonia concentrations by enhancing the metabolism of ammonia to glutamine and urea which is then removed by the kidneys as a componenet of urine.

  • LOLA versus Lactulose

  • LOLA versus Lactulose in Minimal HE.

  • The use of LOLA for people with chronic liver diease including NAFLD/NASH has shown an improvement in liver enzymes.

Who should not take HepLOLA

People with advanced kidney disease should not take HepLOLA.

The degree of kidney disease is measured by the lab value of serum creatinine. People with a serum creatinine ≥ 3mg/dl should not take HepLOLA.

A serum creatinine level of 3 mg/dl is generally equal to an eGFR of 17-25, which is graded as mid to late stage CKD 4.

About Hepatic Encephalopathy

Hepatic Encephalopathy (HE) is an altered level of consciousness as a result of liver disease. Its onset may be gradual oe sudden. Other symptoms may include movement problems, changes in mood, or changes in personality. In advanced stages it can result in coma.

Hepatic Encephalopathy can occur in those with acute or chronic liver disease. Episodes can be triggered by infections, GI bleeding, constipation, electrolyte problems, or certain medications. The underlying mechanism is typically attributed to the buildup of ammonia in the blood, which is normally removed by the liver. The diagnosis is typically based on symptoms, by measuring blood ammonia levels, and electroencephalogram, or a CT scan of the brain.

Hepatic Encephalopathy is often reversible with treatment.